Hye Jin Yoo
Yonsei University, Korea
Title: Relationship between IGF-1 and proinflammatory cytokines with immune function after nutritional support in undernutritioned elderly
Biography
Biography: Hye Jin Yoo
Abstract
Abnormal nutritional status is common in the elderly and undernutrition status leads chronic low-grade increase of levels in circulating cytokine. The aim of this study is to investigate enhancement of insulin-like growth factor-1 (IGF-1) levels, which reflects nutritional status, and its correlation with changes in the cytokine levels after offering nutritional supplementation consisting of extra protein and energy to elderly with a risk of undernutrition. 56 non-diabetic, over 65-year-old participants, who are living independently in a community welfare center for the elderly, with a serum pre-albumin levels under 30 mg/dL and a BMI above 25 kg/m2 were included in data analysis. During 2-week intervention period, all subjects received oral nutrition support. Before and after intervention, they were followed for a 2-week pre- and post-intervention period, respectively; and they were required to maintain routine dietary life during the period. Following 2-week intervention, IGF-1, pre-albumin, transferrin, and total lymphocyte count (TLC) showed greater increase in comparison with the baseline. In addition, body weight was significantly increased, on the other hand, changes in tricep fold thickness were not observed. Interleukin-6 (IL-6) showed greater reduction and tumor necrosis factor-α (TNF-α) levels showed a decreasing tendency. Age had negative correlation with the levels of IGF-1, and had positive correlation with the levels of IL-6 and TNF-α at baseline. The changes from baseline (â–³) in levels of IGF-1 had positive correlation with age and had negative correlation with â–³IL-6 and â–³TNF-α. Based on the study results, we observed enchantment of nutritional status and reduction of cytokine levels through the oral nutritional supplementation during 2 weeks.